Neurofeedback: A Powerful Approach to Enhancing Stroke Recovery

  • out-of-lab
  • neurofeedback

Stroke survivors often face long-term impairments that impact daily life and overall quality of life. While traditional rehabilitation focuses on physical exercises, new strategies aim at the brain’s ability to adapt.

Neurofeedback emerges as a promising approach, offering a pathway to enhance brain recovery. This research investigated whether stroke survivors could improve control over their motor cortex. Specifically through real-time fMRI and mobile EEG neurofeedback.

Neurofeedback EEG fMRI

The Relevance of Neurofeedback

Neurofeedback is becoming increasingly recognized in clinical settings. It holds promise for conditions like stroke. During a stroke, patients lose motor functions and struggle with the slow recovery of these abilities.

Neurofeedback uses the brain’s plasticity—its ability to change and adapt. It offers a new way to complement traditional physical therapies in rehabilitation.

Research Approach

This study was designed as a double-blind, randomized controlled trial with 24 patients. These patients had mild to moderate upper-limb impairments from past strokes.

Researchers used advanced fMRI for neurofeedback and diffusion-weighted imaging to check brain structure. These participants were randomly assigned to either a Real or Sham NF group, and they underwent three NF training sessions. The Real group received direct feedback on their brain activity, while the Sham group received placebo feedback.

The study ran over three training sessions. It measured how the intervention affected motor cortex activity and motor function. The experiment setup is portrayed in the Figure below.

Neurofeedback EEG fMARI
Experimental Setup: The study included three neurofeedback (NF) training sessions, spaced by 24 and 48 hours, along with a baseline session and follow-ups at one week and one month. Participants aimed to control two on-screen bars by moving their stroke-affected hand: the red bar represented activity in the stroke-affected hemisphere, and the blue bar represented the unaffected hemisphere. The goal was to increase the red bar while minimizing the blue bar during movement blocks.

Key Outcomes and Observations

Participants who received actual neurofeedback showed significant ability to control brain activity during the training days. However, these changes did not maintain without continuous feedback. This indicated the need for ongoing sessions.

While motor function improvement was not statistically significant, there were notable enhancements in gross motor skills. The gross motor skills involve larger body movements.

The study also documented changes in brain structure related to the neurofeedback performance. Successful participants exhibited decreased asymmetry in white matter pathways. These are crucial for motor control.

This suggests that effective neurofeedback can induce structural changes in the brain. This could potentially lead to improved motor control and faster recovery.

Enhanced Brain Activity in Key Regions Following NF Training

After NF training, whole-brain analysis revealed significant increases in brain activity within the unaffected hemisphere of the Real group compared to the Sham (see in the image bellow).

Key areas showed increased activity included the putamen, lateral occipital cortex, and parietal operculum cortex. These clusters indicated enhanced activity post-training only in the Real group. The Sham group showing no significant changes in these areas.

Additionally, no direct correlation was found between the initial brain activity during a task and later NF performance within the Real group, suggesting that the training-induced activity changes were not simply a continuation of initial brain states.

Neurofeedback EEG
Brain activity changes were examined before and after Neurofeedback (NF) or Sham training using a controlled visuomotor squeeze task. Three significant clusters showed greater activity changes in the Real group compared to the Sham group, specifically in the putamen, lateral occipital cortex (LOC), and parietal operculum cortex (POC) of the unaffected hemisphere. For clarity, the average percent signal change in these clusters is displayed, along with individual data points (open circles) and error bars indicating the standard error of the mean (SEM).

Broader Implications and Future Directions

The findings underscore neurofeedback’s safety and potential effectiveness. They highlight that with proper training, stroke survivors can refine brain functions. Particularly the ones that directly affect physical abilities.

The research also opened discussions about using EEG neurofeedback. EEG neurofeedback operates on similar principles as fMRI one, but is less invasive and could be more feasible in routine clinical settings.

Neurofeedback is generally safe, tolerated well by patients, and varies in cost. This all makes it a versatile option in stroke rehabilitation. Moreover, it points to the brain’s remarkable ability to adapt to training. All this offers hope for more targeted and effective rehabilitation strategies.

Integrating Neurofeedback with Traditional Therapies

Neurofeedback success varies among individuals. Future studies should investigate how to combine neurofeedback with traditional rehabilitation. This integration could enhance the benefits, leading to greater and more enduring recovery gains for patients.

Cost and Accessibility of Such an Approach

The cost of neurofeedback sessions may concern many people. Treatments usually need multiple sessions for benefits. Insurance coverage and accessibility vary by location and economic status. Yet, the long-term savings on healthcare costs are significant. Faster recovery rates and less use of traditional healthcare support wider use of this technology.

Ethical and Practical Considerations

Like any new medical technology, we must consider the ethics of neurofeedback.

It is vital to use it responsibly and ensure patients understand its benefits and limits. Also, training clinicians to use these systems is important. Making sure that stroke survivors can access them in different healthcare settings is a major challenge.


This study shows neurofeedback’s potential to improve stroke rehabilitation. It offers new insights into how targeted brain training affects recovery. The immediate benefits are promising. Yet, making these improvements last is challenging.

Future research must focus on refining neurofeedback. The goal is to make these advanced recovery techniques more accessible and effective in various healthcare settings.

The full publication can be found in this link:

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